Skip to main content
Content Starts Here GSA Federal Advisory Committee Act (FACA) Database Skip to main content

Committee Detail

Note: An Annual Comprehensive Review, as required by §7 of the Federal Advisory Committee Act, is conducted each year on committee data entered for the previous fiscal year (referred to as the reporting year). The data for the reporting year is not considered verified until this review is complete and the data is moved to history for an agency/department. See the Data From Previous Years section at the bottom of this page for the committee’s historical, verified data.

Details on agency responses to committee recommendations can be found under the Performance Measures section for each committee in the fields “Agency Feedback” and “Agency Feedback Comment.”


HHS - 12153 - Scientific Advisory Committee on Alternative Toxicological Methods - Statutory (Congress Created)
Hide Section - GENERAL INFORMATION

GENERAL INFORMATION

Committee NameScientific Advisory Committee on Alternative Toxicological MethodsAgency NameDepartment of Health and Human Services
Fiscal Year2022Committee Number12153
Original Establishment Date12/19/2000Committee StatusChartered
Actual Termination Date Committee URLhttps://ntp.niehs.nih.gov/whoweare/advisory/ind...
New Committee This FYNoPresidential Appointments*No
Terminated This FYNoMax Number of Members*32
Current Charter Date12/18/2021Designated Fed Officer Position Title*Health Scientist
Date Of Renewal Charter12/18/2023Designated Federal Officer Prefix
Projected Termination Date Designated Federal Officer First Name*Milene
Exempt From Renewal*NoDesignated Federal Officer Middle Name
Specific Termination AuthorityDesignated Federal Officer Last Name*Brownlow
Establishment Authority*Statutory (Congress Created)Designated Federal Officer SuffixPh.D.
Specific Establishment Authority*42USC 285l-3(d), as amendedDesignated Federal Officer Phone*(984) 287-3364
Effective Date Of Authority*12/19/2000Designated Federal Officer Fax*301-480-3009
Exempt From EO 13875 Discretionary CmteNot ApplicableDesignated Federal Officer Email*milene.brownlow@nih.gov
Committee Type*Continuing
Presidential*No
Committee Function*Scientific Technical Program Advisory Board
Hide Section - RECOMMENDATION/JUSTIFICATIONS

RECOMMENDATION/JUSTIFICATIONS

Agency Recommendation*Continue
Legislation to Terminate RequiredNot Applicable
Legislation StatusNot Applicable
How does cmte accomplish its purpose?*The scope and objectives of the Scientific Advisory Committee on Alternative Toxicological Methods (SACATM) are to advise the Interagency Coordinating Committee on the Validation of Alternative Methods (ICCVAM), the National Toxicology Program (NTP) Interagency Center for the Evaluation of Alternative Toxicological Methods (NICEATM), and the Director of the National Institute of Environmental Health Sciences (NIEHS) regarding statutorily mandated duties of ICCVAM and activities of NICEATM. SACATM provides advice on priorities and activities related to the development, validation, scientific review, regulatory acceptance, and national and international harmonization of new, revised, and alternative toxicological test methods. Alternative methods are those that reduce, refine (lessen or avoid pain and/or distress), or replace the use of animals in testing. SACATM also provides input on ways to foster partnerships and communication with interested parties. Meeting information can be found at https://ntp.niehs.nih.gov/events/past/index.html?type=SACATM.
How is membership balanced?*Members are selected from recognized authorities knowledgeable in academia, industry, state government, public health, environmental communities or organizations using new or alternative test methods, as appropriate, in accordance with the statutorily mandated requirements for representation on the SACATM.
How frequent & relevant are cmte mtgs?*Meetings are held at least once each fiscal year. The NIEHS Director appoints voting members to the SACATM, and membership is defined in the ICCVAM Authorization Act of 2000 to include representatives from academia, state government, industry, and animal protection organizations. There was one FY2022 meeting.
Why advice can't be obtained elsewhere?*The quality, scope and balance of advice provided cannot be obtained from NIH staff or from other established sources. Membership is constituted to meet the specific requirements of the mandated mission of the committee and the Institute.
Why close or partially close meetings?NA
Recommendation RemarksThe DFO and Committee Decision Maker positions are held by the same individual due to the assignment of responsibilities within this Institute.

This committee did not produce any reports this fiscal year.

Ex Officio Members: According to the charter language NIH has determined there are 17 Ex Officio positions associated with this committee and the max number of positions includes these members. Currently, no Ex Officio members have been identified and there are no Ex Officio members in the list of current members in this report. It has been the practice of ICCVAM members to send ad hoc attendees according to the topics being discussed rather than having ex officio members formally identified.

Chair: Dr. Nadira K. DeAbrew is serving as Chair.

Dr. Milene Brownlow joined the office in 2022 and assumed the role of DFO and Executive Secretary of the committee.
Hide Section - PERFORMANCE MEASURES

PERFORMANCE MEASURES

Outcome Improvement To Health Or Safety*YesAction Reorganize Priorities*No
Outcome Trust In GovernmentYesAction Reallocate ResourcesNo
Outcome Major Policy ChangesNoAction Issued New RegulationsNo
Outcome Advance In Scientific ResearchYesAction Proposed LegislationNo
Outcome Effective Grant MakingNoAction Approved Grants Or Other PaymentsNo
Outcome Improved Service DeliveryNoAction OtherYes
Outcome Increased Customer SatisfactionYesAction CommentThe Committee makes recommendations to federal staff regarding the Interagency Coordinating Committee on the Validation of Alternative Methods (ICCVAM), the National Toxicology Program (NTP) Interagency Center for the Evaluation of Alternative Toxicological Methods (NICEATM), and the Director of the National Institute of Environmental Health Sciences (NIEHS) regarding statutorily mandated duties of ICCVAM and activities of NICEATM. SACATM provides advice on priorities and activities related to the development, validation, scientific review, regulatory acceptance, implementation, and national and international harmonization of new, revised, and alternative toxicological test methods. Alternative methods are those that reduce, refine (lessen or avoid pain and/or distress), or replace the use of animals in testing. SACATM also provides input on ways to foster partnerships and communication with interested parties.
Outcome Implement Laws/Reg RequirementsNoGrants Review*No
Outcome OtherNoNumber Of Grants Reviewed0
Outcome CommentNANumber Of Grants Recommended0
Cost Savings*Unable to DetermineDollar Value Of Grants Recommended$0.00
Cost Savings CommentMany of the alternative test methods promoted by SACATM may in theory reduce the cost of individual toxicity tests, but it is unclear whether reduced cost per agent tested will be offset by increasing number of agents tested.Grants Review CommentNA
Number Of Recommendations*120Access Contact Designated Fed. Officer*Yes
Number Of Recommendations CommentSACATM met on September 21-22, 2022, virtually. Agenda topics included: (1) Major ICCVAM accomplishments in 2022; (2) Implementing the Strategic Roadmap: Incorporation of Alternatives and Associated Metrics; (3) Validation and Establishing Scientific Confidence in New Approach Methodologies (NAMs); and (4) Computational resources.

For the topic of ICCVAM accomplishments, there were numerous suggestions for additional methods and study endpoints and three recommendations made by the committee including prioritization strategies for ICCVAM and recommending the inclusion of cardiovascular disease, and toxicity as potential topics for future communities of practice webinars.

For the topic of Implementing the Strategic Roadmap, there were six recommendations from the committee including publicizing data on instances where NAMs were used in decision-making prospects, the inclusion of independent NAMs subject matter experts in IACUCs to raise awareness of NAMs and lead to their consideration and use by researchers and regulators,
in addition to numerous suggestions such as continuing stakeholder interactions via workgroups and other consortia to share information on metrics reporting.

For the topic of Scientific Confidence in New Approach Methodologies, there were seven recommendations from the committee including establishing human relevance as the gold standard for comparison of new approach methodologies, adoption of flexible, fit-for-purpose validation frameworks tailored for context of use, and global harmonization of hazard categorization and risk assessment approaches as efficient and effective ways to best support successful harmonization.

Finally, for the topic of Computational Resources, there were three recommendations from the committee including optimization of the existing ICE interface by continued emphasis on controlled vocabulary, metadata, term definitions and annotations, standardization of data presentation, and alignment to biological endpoints.
Access Agency WebsiteYes
% of Recs Fully Implemented*0.00%Access Committee WebsiteYes
% of Recs Fully Implemented CommentDue to the complexity of the recommendations made by this committee, staff is unable to determine which recommendations have been fully or partially implemented solely in response to this committee's activities.Access GSA FACA WebsiteYes
% of Recs Partially Implemented*0.00%Access PublicationsNo
% of Recs Partially Implemented CommentDue to the complexity of the recommendations made by this committee, staff is unable to determine which recommendations have been fully or partially implemented solely in response to this committee's activities.Access OtherNo
Agency Feedback*YesAccess CommentN/A
Agency Feedback Comment*Staff identifies key outcomes of the meeting and reports back to SACATM at the next meeting on developments on the recommendations or advice (either by formal presentation or during discussion).Narrative Description*This committee advises the NIEHS, the Interagency Coordinating Committee on the Validation of Alternative Methods (ICCVAM), and the National Toxicology Program (NTP) Interagency Center for the Evaluation of Alternative Toxicology Methods (Center) regarding ICCVAM activities. They also advise the NIEHS and the NTP Center on the NTP Center's activities.
Hide Section - COSTS

COSTS

Payments to Non-Federal Members*$5,600.00Est Payments to Non-Fed Members Next FY*$5,600.00
Payments to Federal Members*$0.00Est. Payments to Fed Members Next FY*$0.00
Payments to Federal Staff*$79,871.00Estimated Payments to Federal Staff*$82,028.00
Payments to Consultants*$0.00Est. Payments to Consultants Next FY*$0.00
Travel Reimb. For Non-Federal Members*$0.00Est Travel Reimb Non-Fed Members nextFY*$7,264.00
Travel Reimb. For Federal Members*$0.00Est Travel Reimb For Fed Members*$0.00
Travel Reimb. For Federal Staff*$0.00Est. Travel Reimb to Fed Staff Next FY*$0.00
Travel Reimb. For Consultants*$0.00Est Travel Reimb to Consultants Next FY*$0.00
Other Costs$41,070.00Est. Other Costs Next FY*$41,481.00
Total Costs$126,541.00Est. Total Next FY*$136,373.00
Date Cost Last Modified10/13/2022 5:58 PMEst. Fed Staff Support Next FY*0.60
Federal Staff Support (FTE)*0.60Est Cost RemarksProjected costs for FY23 were increased in the event that in-person/hybrid meetings
resume.
Cost RemarksMeetings were held virtually in FY22 due to the ongoing COVID-19 pandemic.

While there was one meeting in FY22, there were $0 in teleconference and videoconference costs because arrangements were made through an office-wide Zoom/WebEx account. Therefore, this expense is not part of the operational costs of the committee for this year.

There is a noticeable increase in federal staff costs between FY21 and FY22 due to a new DFO transitioning to the role on the committee (training by previous DFO), along with the addition of one support staffer to assist with transition. The DFO anticipates this structure to continue in to FY23.
  
Hide Section - Interest Areas

Interest Areas

Category
Area
Medicine
Health and Health Research
Hide Section - MEMBERS,MEETINGS AND ADVISORY REPORTS

MEMBERS,MEETINGS AND ADVISORY REPORTS

To View all the members, meetings and advisory reports for this committee please click here
Hide Section - CHARTERS AND RELATED DOCS

CHARTERS AND RELATED DOCS

No Documents Found
Hide Section - DATA FROM PREVIOUS YEARS

DATA FROM PREVIOUS YEARS

Committee

Data from Previous Years

 
ActionCommittee System IDCommittee NameFiscal Year
 COM-040396Scientific Advisory Committee on Alternative Toxicological Methods2021
 COM-038674Scientific Advisory Committee on Alternative Toxicological Methods2020
 COM-036544Scientific Advisory Committee on Alternative Toxicological Methods2019
 COM-034756Scientific Advisory Committee on Alternative Toxicological Methods2018
 COM-001880Scientific Advisory Committee on Alternative Toxicological Methods2017
 COM-002329Scientific Advisory Committee on Alternative Toxicological Methods2016
 COM-004151Scientific Advisory Committee on Alternative Toxicological Methods2015
 COM-004681Scientific Advisory Committee on Alternative Toxicological Methods2014
 COM-006100Scientific Advisory Committee on Alternative Toxicological Methods2013
 COM-006534Scientific Advisory Committee on Alternative Toxicological Methods2012
 COM-007999Scientific Advisory Committee on Alternative Toxicological Methods2011
 COM-008856Scientific Advisory Committee on Alternative Toxicological Methods2010
 COM-010230Scientific Advisory Committee on Alternative Toxicological Methods2009
 COM-011048Scientific Advisory Committee on Alternative Toxicological Methods2008
 COM-011951Scientific Advisory Committee on Alternative Toxicological Methods2007
 COM-012548Scientific Advisory Committee on Alternative Toxicological Methods2006
 COM-013733Scientific Advisory Committee on Alternative Toxicological Methods2005
 COM-014458Scientific Advisory Committee on Alternative Toxicological Methods2004
 COM-015713Scientific Advisory Committee on Alternative Toxicological Methods2003
 COM-016545Scientific Advisory Committee on Alternative Toxicological Methods2002